Overcoming natural constraints to develop new vancomycin-type antibiotics

This project is exploring the properties of new vancomycin derivatives that will address growing bacterial resistance to these compounds.

Lead organisation(s):

Monash University

Project type:
In progress

AMR bacteria are developing increased resistance to glycopeptide antibiotics (such as vancomycin) –which are last-resort antibiotics used in the clinic to treat serious Gram-positive bacterial infections.

We are utilising a new chemo-enzymatic formation route that we have pioneered to generate and explore the properties of new vancomycin derivatives. This will allow us to explore the structure/function relationships of these crucial antibiotics and to overcome growing bacterial resistance against these compounds.

For more information on this research or activity:

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