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Overcoming natural constraints to develop new vancomycin-type antibiotics
Lead organisation(s):
Monash University
Project type:
Research
Status:
In progress
Summary:
Glycopeptide antibiotics – which include vancomycin – are last-resort antibiotics used in the clinic to treat serious Gram-positive bacterial infections. In this project, my team are utilising a novel chemo-enzymatic formation route that we have pioneered to generate and explore the properties of new vancomycin derivatives. This will allow us to explore the structure/ function relationships of these crucial antibiotics and to overcome growing bacterial resistance against these compounds.
Timeframe:
2016-2024
For more information on this research or activity:
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