Discovery and development of new-generation polymyxins against Gram-negative 'superbugs'

Lead organisation(s): 
Monash University and I (Jian Li, Professor, PhD) am the principal investigator. My project is currently funded by the American National Institutes of Health (NIH). More information at https://www.monash.edu/discovery-institute/news-and-events/news/2019-articles/us-biopharmaceutical-company-licenses-monash-university-superbug-drug-discovery
Project type: 
Research
Status: 
In progress
Summary: 
This project aims to employ novel approaches to discover new-generation polymyxin antibiotics targeting the deadly Gram-negative ‘superbugs’. Novel lead molecules have been licensed to Qpex Biopharma (US) for IND-enabling evaluations with a Phase-I study aimed at 2020.
Timeframe: 
This program originally started in 2009 and will continue for at least another 4 years.
Related topics: 
For aged care
For hospitals
For pharmacy
General public
Objective 5: Research and development
Objective 6: International engagement and partnerships
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