Activity and research directory projects

The directory lists antimicrobial resistance (AMR) activities and research and displays whether they are in progress or completed. Use the filters and search to help refine your query.

17 activities or research projects found
  • 2 August 2019
    The two main objectives of this project is: 1) to engineer micro- and nano-surfaces with enhanced anti-microbial properties and 2) to develop novel technologies to include such functional micro and nano-surfaces on "real-life" objects, overcoming the limitation of micro and nanotechnologies to small areas and flat surfaces.
    Monash University
  • 9 July 2019
    Neisseria gonorrhoeae, the etiological agents of gonorrhoea, is now resistant to all available antibiotics. In the last three years, we have discovered how Neisseria bacteria escape the immune system to cause disease. We are now focused on harnessing this knowledge to develop new options that activate the immune system to control infections.
    Monash University
  • 1 July 2019
    This project aims to employ novel approaches to discover new-generation polymyxin antibiotics targeting the deadly Gram-negative ‘superbugs’. Novel lead molecules have been licensed to Qpex Biopharma (US) for IND-enabling evaluations with a Phase-I study aimed at 2020.
    Monash University and I (Jian Li, Professor, PhD) am the principal investigator. My project is currently funded by the American National Institutes of Health (NIH). More information at https://www.monash.edu/discovery-institute/news-and-events/news/2019-articles/us-biopharmaceutical-company-licenses-monash-university-superbug-drug-discovery
  • 29 June 2019
    Glycopeptide antibiotics – which include vancomycin – are last-resort antibiotics used in the clinic to treat serious Gram-positive bacterial infections. In this project, my team are utilising a novel chemo-enzymatic formation route that we have pioneered to generate and explore the properties of new vancomycin derivatives. This will allow us to explore the structure/ function relationships of these crucial antibiotics and to overcome growing bacterial resistance against these compounds.
    Monash University
  • 29 June 2019
    In this project, my team is developing a new approach to tackling antimicrobial resistance that exploits alternate mechanisms to overcome bacterial infections through augmentation of host immune responses and removal of bacterial evasion mechanisms. Our simultaneous “drug-immune” therapies will provide highly synergistic bacterial killing utilising existing antibiotic therapeutics, thus underlining the feasibility of future clinical application of such approaches.
    Monash University
  • 27 June 2019
    We are working with clinicians in the Center for Innovative Phage Applications and Therapeutics at the University of California in San Diego. Phage therapy is frontier medicine, and has FDA approval for use in hospitals in the USA. Isolating clinically-effective "cocktails" is a challenge that can only be met by collaboration between research scientists trained in phage biology (Monash) and clinicians with experience in clinical deployment (UCSD).
    Monash University.
    University of California in San Diego.
  • 27 June 2019
    We have engaged with partners in Wenzhou, China to analyze the recent rise in AMR in their hospitals. In 2019, we opened the Monash BDI-WMU Alliance in Clinical and Experimental Biomedicine on the campus of Wenzhou Medical University. Initial assessments of one species of bacteria reveals that 15 years ago, less than ten patients per annum were infected, all of which responded to off the shelf antibiotics. Last year, 990 patients had infections s, with ~1 in 3 being AMR.
    Biomedicine Discovery Institute, Monash University, Australia.
    Wenzhou Medical University, China.
  • 5 July 2018
    This project is an initiative of WARRA, the Wollongong Antimicrobial Resistance Research Alliance. This project aims to develop and investigate the psychometric properties of a questionnaire measuring factors contributing to antibiotic use within the community, utilising the Theory of Planned Behaviour as a means of predicting problematic behaviour with antibiotics and informing future intervention strategies.
    University of Wollongong
  • 5 July 2018
    WARRA, the Wollongong Antimicrobial Resistance Research Alliance, has developed a workshop series initiative with the aim of engaging pharmacists in the Illawarra Shoalhaven region. The workshop series will provide a continuing professional development (CPD) accredited platform for pharmacists to engage with researchers regarding antibiotic use and antimicrobial resistance.
    University of Wollongong
  • 5 July 2018
    This project is an initiative of WARRA, the Wollongong Antimicrobial Resistance Research Alliance. This project aims to identify the trends in antimicrobial resistance over a 10 year period across the Illawarra Shoalhaven region for organisms including staphylococcus aureus, escherichia coli, klebsiella pneumonia, enterobacter spp, pneumococcus and haemophilus influenza. It further aims to determine the evolution of antimicrobial resistance in an individual over time.
    University of Wollongong, Illawarra Shoalhaven Local Health District, NSW Health Pathology, Southern IML

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