Activity and research directory projects
The directory lists antimicrobial resistance (AMR) activities and research and displays whether they are in progress or completed. Use the filters and search to help refine your query.16 activities or research projects found
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- 2 June 2020Communicable Diseases Intelligence (CDI) is a peer-reviewed scientific journal published by the Office of Health Protection, Department of Health. The journal aims to disseminate information on the epidemiology, surveillance, prevention and control of communicable diseases of relevance to Australia.Office of Health Protection, Australian Government Department of Health
- 15 April 2020Ausgem is using genomic sequencing to characterise Escherichia coli that cause urinary tract infections and sepsis in Australian hospitals. Our studies are focussing on the carriage of mobile antimicrobial resistance (AMR) genes and virulence genes in these cohorts and comparing these elements with those circulating in food production systems and from environmental and wildlife sources enabling policy makers to make informed regulatory choices regarding antimicrobials and biosecurity.AusGEM (Partnership between University of Technology and NSW Department of Primary Industries).
- 2 August 2019The two main objectives of this project is: 1) to engineer micro- and nano-surfaces with enhanced anti-microbial properties and 2) to develop novel technologies to include such functional micro and nano-surfaces on "real-life" objects, overcoming the limitation of micro and nanotechnologies to small areas and flat surfaces.Monash University
- 1 July 2019This project aims to employ novel approaches to discover new-generation polymyxin antibiotics targeting the deadly Gram-negative ‘superbugs’. Novel lead molecules have been licensed to Qpex Biopharma (US) for IND-enabling evaluations with a Phase-I study aimed at 2020.Monash University and I (Jian Li, Professor, PhD) am the principal investigator. My project is currently funded by the American National Institutes of Health (NIH). More information at https://www.monash.edu/discovery-institute/news-and-events/news/2019-articles/us-biopharmaceutical-company-licenses-monash-university-superbug-drug-discovery
- 29 June 2019Glycopeptide antibiotics – which include vancomycin – are last-resort antibiotics used in the clinic to treat serious Gram-positive bacterial infections. In this project, my team are utilising a novel chemo-enzymatic formation route that we have pioneered to generate and explore the properties of new vancomycin derivatives. This will allow us to explore the structure/ function relationships of these crucial antibiotics and to overcome growing bacterial resistance against these compounds.Monash University
- 29 June 2019In this project, my team is developing a new approach to tackling antimicrobial resistance that exploits alternate mechanisms to overcome bacterial infections through augmentation of host immune responses and removal of bacterial evasion mechanisms. Our simultaneous “drug-immune” therapies will provide highly synergistic bacterial killing utilising existing antibiotic therapeutics, thus underlining the feasibility of future clinical application of such approaches.Monash University
- 27 June 2019We are working with clinicians in the Center for Innovative Phage Applications and Therapeutics at the University of California in San Diego. Phage therapy is frontier medicine, and has FDA approval for use in hospitals in the USA. Isolating clinically-effective "cocktails" is a challenge that can only be met by collaboration between research scientists trained in phage biology (Monash) and clinicians with experience in clinical deployment (UCSD).Monash University.
University of California in San Diego.
- 27 June 2019We have engaged with partners in Wenzhou, China to analyze the recent rise in AMR in their hospitals. In 2019, we opened the Monash BDI-WMU Alliance in Clinical and Experimental Biomedicine on the campus of Wenzhou Medical University. Initial assessments of one species of bacteria reveals that 15 years ago, less than ten patients per annum were infected, all of which responded to off the shelf antibiotics. Last year, 990 patients had infections s, with ~1 in 3 being AMR.Biomedicine Discovery Institute, Monash University, Australia.
Wenzhou Medical University, China.
- 7 August 2018This PhD research project is aimed at investigating alternative regulatory and funding models for antimicrobial drugs. The current economic model (where sales volumes and price determine the return on investment for a drug) does not foster appropriate antimicrobial use. Financial risks associated with AMR has resulted in a decline in the marketing of new drugs & insecurity of supply of current antimicrobials. This project is focused on the Australian market within a global context.University of Adelaide
- 5 July 2018This project is an initiative of WARRA, the Wollongong Antimicrobial Resistance Research Alliance. This project aims to identify the trends in antimicrobial resistance over a 10 year period across the Illawarra Shoalhaven region for organisms including staphylococcus aureus, escherichia coli, klebsiella pneumonia, enterobacter spp, pneumococcus and haemophilus influenza. It further aims to determine the evolution of antimicrobial resistance in an individual over time.University of Wollongong, Illawarra Shoalhaven Local Health District, NSW Health Pathology, Southern IML